Autism microbiome review. Apr 15, 2024 · The inclusion criteria for the review were observation...
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Autism microbiome review. Apr 15, 2024 · The inclusion criteria for the review were observational prospective and retrospective studies, case–control studies, randomized controlled trials (RCTs) or cohort studies investigating gut bacteria in children aged 2–18 years diagnosed with autism or ASD. Autism spectrum disorder (ASD) is a complex neurodevelopmental condition with a steadily increasing global prevalence, yet its etiology remains largely Broad Institute is a multidisciplinary community of researchers on a mission to improve human health. . This narrative review synthesizes recent clinical and metagenomic evidence on oral microbiome alterations in ASD and critically evaluates the potential pathways through which these microbial imbalances may impact neurodevelopmental outcomes. Understanding these connections may open new avenues for targeted treatments in ASD management. Dec 22, 2025 · Similar content being viewed by others Gut microbiome composition and strain-sharing in multiplex autism spectrum disorder families Article Open access 26 February 2026 Nov 29, 2025 · This review explores the latest evidence on microbiome alterations in ASD, the mechanisms by which gut dysbiosis influences neurodevelopment, and the therapeutic potential of microbiome-based interventions. Methods We performed a systematic literature review according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Checklist [12] to analyze the current state of knowledge on gut microbiota abnormalities in children with autism spectrum disorder. Nov 25, 2024 · This review aims to provide a comprehensive analysis of current findings on the relationship between the gut and oral microbiota with ASD, and a particular focus on studies utilizing 16S rRNA sequencing. 1. Introduction Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition characterized by deficits in social communication and restricted, repetitive behaviors. This review integrates the findings of recent years on the gut microbiota and ASD association, mainly focusing on the characterization of specific microbiota that leads to ASD and addressing potential therapeutic interventions to restore a healthy balance of gut microbiome composition that can treat autism-associated symptoms. For autism, anorexia and ADHD, this raises a provocative question: are clinicians sometimes treating brain-based symptoms while missing a shared biological terrain in the gut? This narrative review synthesizes recent clinical and metagenomic evidence on oral microbiome alterations in ASD and critically evaluates the potential pathways through which these microbial imbalances may impact neurodevelopmental outcomes. For autism, anorexia and ADHD, this raises a provocative question: are clinicians sometimes treating brain-based symptoms while missing a shared biological terrain in the gut? 2. We would like to show you a description here but the site won’t allow us. They also appear to influence many aspects of your overall health, both within your digestive system and outside of it. The included articles had to include information about the sample size and gut Sep 26, 2025 · This systematic review highlights the potential of microbiome-targeted therapies for improving both behavioral and GI symptoms in individuals with ASD. In this narrative review, we synthesize recent clinical and metagenomic evidence on oral microbiome alterations in ASD and critically evaluate the potential pathways through which these microbial imbalances may impact neurodevelopmental outcomes. 1 day ago · The data suggest that an unstable microbiome may nudge hormone levels off course, subtly shifting behaviour and mental state over time. Sep 13, 2024 · The primary aim of this review is to present a comprehensive overview of the current clinical and mechanistic associations between ASD and gut microbiota, elucidating how this understanding informs the observed etiological variances in individuals with autism spectrum disorder concerning their gut microbiome. Last updated on 08/18/2023. Aug 18, 2023 · Gut Microbiome Medically Reviewed. Increasing evidence implicates peripheral systems—particularly the gut microbiome—in ASD etiology [1,2]. FMT, in particular, consistently showed the most positive results across the studies included in our review, especially in reducing ASD severity and improving GI function. The gut–brain axis (GBA) represents bidirectional communication between the gastrointestinal tract and In this narrative review, we synthesize recent clinical and metagenomic evidence on oral microbiome alterations in ASD and critically evaluate the potential pathways through which these microbial imbalances may impact neurodevelopmental outcomes. The trillions of microorganisms that live there affect each other and their environment in various ways. Your gut microbiome is a microscopic world within the world of your larger body.
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